As in the sense, He had a stroke which left him paralyzed on the left side.
I’d never realized it before but this was formerly the stroke of God’s hand.
Stroke, 6. An attack of disease. a. An apoplectic or (now more usually) paralytic seizure. Formerly the stroke of God’s hand.
1599 A. M. tr. Gabelhouer’s Bk. Physic 25/2 An excellent Cinnamome water for the stroke of Gods hande.
Acknowledgements to Done With Mirrors, where I chanced upon this.