ladybird. Yes, Romeo and Juliet is the earliest recorded use, but the word was almost certainly in wide oral use when Shakespeare wrote his play.
Out of interest, how is this determined?
half-blooded. Shakespeare may get credit for the adjective, but the noun is half a century older.
ie the noun half-blood, right?
Of the six that you give as fairly firm Shakespearisms, five appear to have been formed in regular and unspectacular fashion from pre-existing English words and affixes.
I am curious about the sixth, scuffle. Etymonline gives it from 1570, from scuff, “of Scandinavian origin”. ODoE says “late 16th century, probably of Scandinavian origin, compare with Swedish skuffa ‘to push’.